Introduction: Viral keratoconjunctivitis (VKC) is a common ocular condition characterized by inflammation of the conjunctiva and cornea, often caused by adenoviruses. It is highly contagious and can lead to significant morbidity, including blurred vision and discomfort. This study investigates an epidemic of VKC in a tertiary care hospital, focusing on its clinical presentation, epidemiological factors, and outcomes. Materials and Methods: A prospective observational study was conducted on 300 patients presenting with symptoms of VKC over six months. Inclusion criteria included clinical signs of VKC, such as redness, watering, and photophobia, while exclusion criteria involved bacterial or allergic conjunctivitis. Diagnostic tests included PCR for adenovirus and slit-lamp examination. Results: Of the 300 patients, 85% tested positive for adenovirus. The mean age was 32.5 years, with a male predominance (60%). Common symptoms included redness (95%), watering (90%), and photophobia (85%). Age >50 years and delayed presentation were significant risk factors for severe disease. Immunocompromised Status (25% of Severe Cases). Most patients experienced symptoms for 1–2 weeks, consistent with the natural course of adenoviral conjunctivitis. More than 2 Weeks (20%) are Prolonged symptoms were observed in a subset of patients, likely due to corneal involvement or delayed treatment. Persistent Blurred Vision (15%) are complication underscores the potential long-term impact of VKC on visual function. Conclusion: The epidemic was predominantly caused by adenovirus, with significant morbidity. Early diagnosis and strict infection control measures are essential to prevent outbreaks.