Diabetes mellitus (DM) is a metabolic disease associated with chronic hyperglycemia. It is a distressing epidemic and is considered one of the leading causes of death worldwide. Globally, the prevalence of DM is estimated to be 9.3% (463 million people), increasing to 10.2% (578 million) and 10.9% (700 million) by 2030 and 2045, respectivelyThe relationship between glycated hemoglobin (HbA1c) levels and intraocular pressure (IOP) in patients with diabetes mellitus (DM) is a subject of significant clinical interest due to its implications for glaucoma risk and diabetic eye disease progression. Material and methods This is a prospective and observational study was conducted in the Department of Ophthalmology, Dr. VRK Women's Medical College, Teaching Hospital & Research Centre. Subjects with provisional diabetes were confirmed to be having diabetes by re-estimating fasting blood glucose by enzymatic assay- based glucose oxidation method. The biochemical analyses done using the Merck Micro Lab 120, semi-automated analyzer included total serum cholesterol (CHOD-POD method), high-density lipoproteins (after protein precipitation CHOD-POD method), serum triglycerides (CHOD-POD), hemoglobin (calorimetric hemoglobinometer), packed cell volume (capillary method) and the glycosylated hemoglobin fraction. Results A total of 120 patients involving 240 eyes of Type 2 diabetes mellitus patients who satisfied the inclusion criteria were included in our study. Out of 120, 76 patients were male (63.3%), and 44 patients were female (36.7%). The patients ranged between the ages of 40-89 years. The mean age was 59.62 years with a standard deviation of 9.76. The mean intraocular pressure in males was 15.6 ± 2.9 mmHg, and in females, the mean intraocular pressure was 15.5 ± 3.2 mmHg Conclusions Systemic hypertension, smoking, pulse rate and CCT were associated with elevated intraocular pressure in type 2 DM. Women with type 2 DM, especially those with CSME, were more prone to have an elevated IOP.